Heteropoly Acid Catalyzed Hydroamination of Alkenes
نویسندگان
چکیده
منابع مشابه
Enantio- and regioselective CuH-catalyzed hydroamination of alkenes.
A highly enantio- and regioselective copper-catalyzed hydroamination reaction of alkenes has been developed using diethoxymethylsilane and esters of hydroxylamines. The process tolerates a wide variety of substituted styrenes, including trans-, cis-, and β,β-disubstituted styrenes, to yield α-branched amines. In addition, aliphatic alkenes coupled to generate exclusively the anti-Markovnikov hy...
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N-Alkenyl carboxamides undergo gold-catalyzed intramolecular exo-hydroamination to form nitrogen heterocycles in excellent yield.
متن کاملEnantioselective CuH-Catalyzed Anti-Markovnikov Hydroamination of 1,1-Disubstituted Alkenes
Enantioselective synthesis of β-chiral amines has been achieved via copper-catalyzed hydroamination of 1,1-disubstituted alkenes with hydroxylamine esters in the presence of a hydrosilane. This mild process affords a range of structurally diverse β-chiral amines, including β-deuterated amines, in excellent yields with high enantioselectivities. Furthermore, catalyst loading as low as 0.4 mol% c...
متن کاملRhodium-catalyzed asymmetric intramolecular hydroamination of unactivated alkenes.
Metal-catalyzed enantioselective intramolecular hydroamination of olefins1 is one of the most conceptually simple and atom-economical approaches to the construction of enantioenriched nitrogen heterocycles,2 which are valuable synthons in the preparation of natural products and biologically active molecules.3 Despite significant advances,4,5,6 no general solution for this challenging transforma...
متن کاملIridium-catalyzed intermolecular hydroamination of unactivated aliphatic alkenes with amides and sulfonamides.
The intermolecular addition of N-H bonds to unactivated alkenes remains a challenging, but desirable, strategy for the synthesis of N-alkylamines. We report the intermolecular amination of unactivated α-olefins and bicycloalkenes with arylamides and sulfonamides to generate synthetically useful protected amine products in high yield. Mechanistic studies on this rare catalytic reaction revealed ...
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ژورنال
عنوان ژورنال: Synfacts
سال: 2008
ISSN: 1861-1958,1861-194X
DOI: 10.1055/s-2008-1078442